ewly prepared Schiff bases; 2-hydroxybenzylidene-4-x-phenyl)-2-aminothiazole, where x=H, NO2-, CH3, -OCH3, -Cl, and –F (L1-L6), and their corresponding Pt (II) complexes (Pt(L1)2-Pt(L6)2) were synthesized. The ligands and their own complexes were structurally characterized using, FT-IR, 1HNMR, 13CNMR, mass spectra, elemental analysis and SEM technique. The spectral data revealed that these bases are bonded to the Pt ion via both, the deprotonated hydroxyl and the imine groups, suggesting a square planar geometry. Human DNA interaction with Schiff bases and their metal complexes were investigated spectrophotometrically, intercalation mechanism was found to dominate those links. Antioxidant activity measurements of the prepared ligands and their platinum complexes, also, were performed by linoleic acid free radical scavenging method. The methoxy derivative, L4 was found to be the most active species relatively to BHT and the sequence of activity, apparently arranged as following order:
L4> L3> L2> L5=L6> L1
Anti-proliferative activity of the bases and their Pt (II) complexes was carried out on the MCF-7 cancer cell lines following the MTT assay.