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26373

Design, Synthesis, and Biological Evaluation of N-Phenylpyrazole Derivatives Featuring Nitrogen-Containing Side Chains as Potent Antitumor Agents

Article

Last updated: 22 Jan 2023

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Subjects

-

Tags

Organic chemistry

Abstract

A series of novel N-phenylpyrazole containing acyl derivatives 3a, b, N-methylimidiazole 4, thiazole derivatives 6a-d, benzimidiazole derivatives 7a-c pyrane and pyridine 8, 9a, b, tetrazole 10, pyridodipyrimidine 11, and dihydronaphthaline derivatives 15 have been synthesized. The structure of the newly synthesized compounds was elucidated by IR, 1H NMR, 13C NMR, Mass spectra and Elemental analysis. The newly synthesized compounds were evaluated for their antitumor activity against three tumor cell lines, liver cancer (HepG2), human colonic carcinoma cell line (HCT-116), and human breast adenocarcinoma (MCF-7). Compounds 6d, 7b, c, 9b and 11 exhibited higher antitumor activity compared with the reference drug Doxorubicin.

DOI

10.21608/ejchem.2019.6773.1565

Keywords

N-pyrazolyl derivatives, hexahydropyridodipyrimidine-4, 6-dione, antitumor activity

Authors

First Name

Hend

Last Name

Hafez

MiddleName

Nagah

Affiliation

Photochemistry department, National Research center, Chemical Industrial Section, DokKi, Gizza

Email

dr.hendhafez@yahoo.com

City

Giza

Orcid

0000-0003-1541-8744

First Name

Abdel-Rhman

Last Name

El-Gazzar

MiddleName

Barakat

Affiliation

Al-Imam Mohammad Ibn Saud Islamic University (IMSIU), Faculty of Science, Department of Chemistry

Email

profelgazzar@yahoo.com

City

Riyadh

Orcid

-

First Name

Ahmed

Last Name

Ali

MiddleName

Salah

Affiliation

Photochemistry Department, National Research Centre, Cairo, Egypt

Email

a_saly@yahoo.com

City

Giza

Orcid

-

First Name

Abbas Alakhras

Last Name

Alakhras

MiddleName

Ishak

Affiliation

Al-Imam Mohammad Ibn Saud Islamic University (IMSIU), Faculty of Science, Department of Chemistry, Riyadh

Email

aakhrasi@imamu.edu.sa

City

Riyadh

Orcid

-

Volume

62

Article Issue

6

Related Issue

5761

Issue Date

2019-06-01

Receive Date

2018-12-20

Publish Date

2019-06-01

Page Start

1,093

Page End

1,104

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 62_Issue 6_Pages 1093-1104.pdf

PDF . 1.2MB

Link

https://ejchem.journals.ekb.eg/article_26373.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=26373

Order

10

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023