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24138

Development of Smart Alginate/chitosan Grafted Microcapsules for Colon Site-specific Drug Delivery

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Polymer chemistry

Abstract

In this study, a smart delivery system for colon site-specific release of diclofenac sodium (DS) was developed based on alginate grafted chitosan (Alg-g-CS) microcapsules. The developed microcapsules were characterized using FTIR and SEM characterization tools, while the present amine content on the alginate microcapsules surface was estimated by ion exchange capacity (IEC) measurements. Besides, both swelling and in vitro drug release profiles were studied at colon pH medium (pH7.4). The results showed an increase in IEC values from 1.1 to 3.6meq/g with increasing CS concentration from 0.1 to 0.5%. Moreover, grafting of alginate microcapsules with chitosan prevented the drug burst release as well as protected alginate microcapsules from the fast disintegration at colon conditions. The gained results clearly suggested that the developed smart Alg-g-CS (0.5%CS) microcapsules could be used effectively for the delivery of diclofenac sodium (DS) to colon tract.

DOI

10.21608/ejchem.2019.6716.1562

Keywords

Alginate, Chitosan, Drug delivery, diclofenac sodium

Authors

First Name

M.

Last Name

Taher

MiddleName

A.

Affiliation

Department of Chemistry, Faculty of Science, AL-Azhar University (Assuit Branch), Egypt

Email

amo101981@yahoo.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Omer

MiddleName

M.

Affiliation

Polymer Materials Research Department, Advanced Technology and New Materials Research Institute, City for Scientific Research and Technological Applications (SRTA-City), New Borg El-Arab City, P.O: Box: 21934, Alexandria, Egypt

Email

ahmedomer_81@yahoo.com

City

-

Orcid

-

First Name

A.

Last Name

Hamed

MiddleName

M.

Affiliation

Department of Chemistry, Faculty of Science, AL-Azhar University (Assuit Branch), Egypt

Email

abdo8522@yahoo.com

City

-

Orcid

-

First Name

A.

Last Name

Ali

MiddleName

M.

Affiliation

Polymer Materials Research Department, Advanced Technology and New Materials Research Institute, City for Scientific Research and Technological Applications (SRTA-City), New Borg El-Arab City, P.O: Box: 21934, Alexandria, Egypt

Email

aly.aly88@yahoo.com

City

-

Orcid

-

First Name

T.

Last Name

Tamer

MiddleName

M

Affiliation

City of Scientific Research and technological applications (SRTA)

Email

ttamer85@gmail.com

City

New Borg Elarab

Orcid

0000-0002-6203-7488

First Name

M.

Last Name

Mohy Eldin

MiddleName

S.

Affiliation

Polymer Materials Research Department, Advanced Technology and New Materials Research Institute, City for Scientific Research and Technological Applications (SRTA-City), New Borg El-Arab City, P.O: Box: 21934, Alexandria, Egypt

Email

mohyeldinmohamed@gmail.com

City

-

Orcid

-

Volume

62

Article Issue

6

Related Issue

5761

Issue Date

2019-06-01

Receive Date

2018-12-17

Publish Date

2019-06-01

Page Start

1,037

Page End

1,045

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 62_Issue 6_Pages 1037-1045.pdf

PDF . 1.3MB

Link

https://ejchem.journals.ekb.eg/article_24138.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=24138

Order

6

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Development of Smart Alginate/chitosan Grafted Microcapsules for Colon Site-specific Drug Delivery

Details

Type

Article

Created At

22 Jan 2023