The manganese based MOF (Mn(BDC)(H2O)2); was successfully synthesized via a microwave method. The features of the Mn-MOF was evaluated by XRD, TGA, N2 adsorption-desorption at -196ºC, FTIR and SEM. The elimination of heavy metal ions from aqueous solution via Mn-MOF was described by batch adsorption tests including kinetic and thermodynamic models. Mn-MOF exhibited a very high adsorption efficiency towards Cd(II), Pb(II) and Hg(II) from aqueous solution (81.89%, 71.19% and 65.19% respectively). Adsorption kinetics data evidenced that heavy metal ions adsorption isotherms appropriated the Langmuir model and conform the pseudo-second-order kinetic equation. Successfully, the Mn-MOF was reused illustrative in the first run, the adsorbed amounts for (Cd(II), pb(II) and Hg(II)) were (80.2%, 69.6% and 64%) after fifth run became (68%, 54.74% and 50.98% respectively) which is elucidating its potential for heavy metal ions decontamination application.