In this study, formulation of manual dishwashing liquid detergent with ionic, nonionic and zwitterionic surfactants mixtures were investigated in respect to viscosity, cloud point, foaming power, foam features, washing performance, irritation test, in addition to its cost, in comparison with that produced by multinational companies in their own factories in Egypt. It has been found that the formulations containing Linear alkyl benzene sulphonic acid are characterized by higher performance of removing stain, without any stain deposition on dishes, in addition to moderate foaming power which is diminished with hard water. Our proposed formulations 10% Sodium alkylbenzene sulfonate with 2% sodium laurylether sulphate and 2% coconut diethanolamide or 2% Cocamidopropylamine Oxide have resulted in better washing performances, less irritations, higher viscosity, comparable cloud points and lower cost than multinational market products H and P which contain 12% Sodium linear alkylbenzene sulfonate with 6% sodium laurylether sulphate and 9% sodium laurylether sulphate and 6% Cocamidopropylamine oxide respectively.