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The Antiproliferative Activity and Molecular Docking Studies of Some Sulfonamides against Cancer Cell Lines Compared to Normal Cells

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Organic chemistry

Abstract

Some new and known substituted 1,2,3,4-tetrahydroacridines incorporated at their position nine with various sulfa drug or thiosemicarbazide moieties were synthesized. Biologically, these compounds were investigated for their antiproliferative activity against human breast cancer (MCF-7) cell line compared to murine fibroblast normal cell line (BALB/3T3). The results were calculated as the IC50 (inhibitory concentration 50%) compared with Cisplatin as control. Furthermore, a docking simulation study was carried out to predict the inhibitory mode of action of the most active compounds.

DOI

10.21608/ejchem.2018.2934.1242

Keywords

Antiproliferative activity, sulphonamides, MCF-7, BALB/3T3, Molecular docking

Authors

First Name

Abdel-Mohsen

Last Name

Soliman

MiddleName

M.

Affiliation

Department of Therapeutic Chemistry National Research Centre, El-Buhouth St., P.O. 12622, Dokki, Giza, Egypt

Email

amsolimannrc@gmail.com

City

cairo

Orcid

0000-0001-8816-5309

First Name

Mohsen

Last Name

Kamel

MiddleName

-

Affiliation

Department of Therapeutic Chemistry National Research Centre, El-Buhouth St., P.O. 12622, Dokki, Giza, Egypt

Email

mohsenmkamel44@yahoo.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Eweas

MiddleName

F.

Affiliation

Department of Therapeutic Chemistry National Research Centre, El-Buhouth St., P.O. 12622, Dokki, Giza, Egypt

Email

eweas1@gmail.com

City

-

Orcid

-

First Name

Joanna

Last Name

Wietrzyk

MiddleName

-

Affiliation

Laboratory of Experimental Anticancer Therapy, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114 Wroclaw, Poland

Email

wietrzyk@iitd.pan.wroc.pl

City

-

Orcid

-

First Name

Magdalena

Last Name

Milczarek

MiddleName

-

Affiliation

Laboratory of Experimental Anticancer Therapy, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114 Wroclaw, Poland

Email

milczarek@iitd.pan.wroc.pl

City

-

Orcid

-

Volume

61

Article Issue

3

Related Issue

1396

Issue Date

2018-06-01

Receive Date

2018-02-14

Publish Date

2018-06-01

Page Start

423

Page End

429

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 61_Issue 3_Pages 423-429.pdf

PDF . 582.6kB

Link

https://ejchem.journals.ekb.eg/article_7317.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=7317

Order

4

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

The Antiproliferative Activity and Molecular Docking Studies of Some Sulfonamides against Cancer Cell Lines Compared to Normal Cells

Details

Type

Article

Created At

22 Jan 2023