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3753

Genetic Variants of Interleukin-18 Promoter Gene in Coronary Artery Disease

Article

Last updated: 22 Jan 2023

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Subjects

-

Tags

Biochemistry

Abstract

Background & objectives: Heart disease is impacted by ecological and inherited factors. Interleukin-18 (IL-18) is a pro-inflammatory cytokine that stimulates the immune reaction and induces the formation of atherosclerotic plaques. The aim of this study was to determine the relation between IL-18 promoter variants at (607C/A) and (137G/C) sites and coronary artery disease (CAD).
Subjects & Methods: A sum of one hundred and twenty Egyptian patients (Sixty with CAD and sixty without CAD) and fifty healthy controls were consolidated into the study. Genotyping of IL18 promoter gene was investigated by PCR - Specific Sequence primer (PCR-SSP) technique .
Results: The outcomes demonstrated that a significant association between lipid profiles and risk for CAD. At position-137, the recurrence of GG genotype was fundamentally connected with CAD. No qualifications in the genotypic and allelic frequencies amongst cases and controls were found for IL-18 (607C/A) promoter gene.
Conclusion: A relationship between IL-18 (137G/C) promoter gene and vulnerability to CAD was proposed and it might serve as susceptibility biomarkers in the pathogenesis of atherosclerosis.

DOI

10.21608/ejchem.2017.1337.1085

Keywords

Coronary artery disease (CAD), Inflammation, Interleukin-18 (IL-18), Gene polymorphism

Authors

First Name

Lamiaa

Last Name

Mageed

MiddleName

-

Affiliation

Biochemistry Department, Genetic Engineering and Biotechnology Division, National Research Centre (NRC), Giza-Egypt

Email

malakalhoda@yahoo.com

City

cairo

Orcid

-

First Name

Ibrahim H.

Last Name

Borai

MiddleName

-

Affiliation

Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt

Email

prof.ibrahimhassan@yahoo.com

City

Caairo

Orcid

-

First Name

Nahla S.

Last Name

Hassan

MiddleName

-

Affiliation

Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt

Email

nana_samir@hotmail.com

City

Cairo

Orcid

-

First Name

Olfat

Last Name

Shaker

MiddleName

G.

Affiliation

Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University

Email

olfatshaker@yahoo.com

City

-

Orcid

-

First Name

Esmat

Last Name

Ashour

MiddleName

-

Affiliation

Biochemistry Department, Genetic Engineering and Biotechnology Division, National Research Centre (NRC), Giza-Egypt

Email

esmatashour3@gmail.com

City

Giza

Orcid

0000-0002-2477-6132

First Name

Mohammed

Last Name

El Badrawy

MiddleName

-

Affiliation

The National Heart Institute, Giza, Egypt

Email

mobadrawydr@hotmail.com

City

Giza

Orcid

-

First Name

Olfat M.

Last Name

Fawzi

MiddleName

-

Affiliation

Biochemistry Department, Genetic Engineering and Biotechnology Division, National Research Centre (NRC), Giza-Egypt

Email

olfat.darwish@yahoo.com

City

Giza

Orcid

-

Volume

60

Article Issue

5

Related Issue

630

Issue Date

2017-10-01

Receive Date

2017-07-18

Publish Date

2017-10-01

Page Start

883

Page End

891

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 60_Issue 5_Pages 883-891.pdf

PDF . 1.1MB

Link

https://ejchem.journals.ekb.eg/article_3753.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=3753

Order

13

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023