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3685

Influence of Poloxmer on the Dissolution Properties of Mosapride and Its Pharmaceutical Tablet Formulation

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Last updated: 01 Jan 2025

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Abstract

This work was an attempt to improve therapeutic efficacy and increase patient compliance thereby formulating immediate release of Mosapride citrate's tablets with improved physical and chemical characteristics. The tablet form was prepared by wet granulation of Mosapride with a binder solution of Poloxmer 407 and compressed the dried granules of Mosapride into non-friable, stable tablets. The other objective, the performance of two classes of superdisintegrants as croscarmellose sodium (Ac-Di-Sol), and sodium starch glycolate (Primojel) in dissolution of Mosapride immediate release and promoting disintegration tablets was evaluated. The post-compression and the pre-compression parameters were characterized which within their respective standards must lie. Chemical composition and crystallinity were investigated via FTIR and XRD, respectively. The post compression parameters such as thickness test, hardness, friability testes and in vitro drug release studies were also performed.

DOI

10.21608/ejchem.2017.3685

Keywords

dissolution enhancement, Croscarmellose sodium, Mosapride, Poloxmer, sodium starch glycolate

Volume

60

Article Issue

3

Related Issue

567

Issue Date

2017-06-01

Receive Date

2016-10-30

Publish Date

2017-06-01

Page Start

443

Page End

451

Print ISSN

0449-2285

Online ISSN

2357-0245

Link

https://ejchem.journals.ekb.eg/article_3685.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=3685

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8

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Influence of Poloxmer on the Dissolution Properties of Mosapride and Its Pharmaceutical Tablet Formulation

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Article

Created At

22 Jan 2023