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3286

Facile Synthesis and Structural Characterization of Some Phthalazin-1(2H)-one Derivatives as Antimicrobial Nucleosides and Reactive Dye

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Organic chemistry

Abstract

Abstract: A new series of 2,4-disubstituted phthalazin-1(2H)-one derivatives was synthesized via nucleophilic attach of N-2 of phthalazin-1(2H)-one derivatives on different monosuccharides. Synthesis of phthalazinone nucleosides were very effective as antimicrobial. Also the phthalazinone moiety can be used in synthesis of reactive nucleosides and dyes that was chemically bonded with proteins and fibers respectively as afforded highly stability of dyestuff wool and cotton textiles. The structure of the prepared compounds was elucidated by physical and spectral data like FT-IR, 1H- and 13C-NMR.

DOI

10.21608/ejchem.2017.915.1043

Keywords

Keywords: phthalazin-1(2H)one, allyl-, propargyl-phthalazinone, epchlorohydrin, Nucleosides, Reactive dye

Authors

First Name

Maher

Last Name

EL-Hashash

MiddleName

-

Affiliation

Department of Organic Chemistry, Faculty of Science, University of Ain Shams

Email

maheraahashasha49@ahoo.com

City

CAIRO

Orcid

-

First Name

Sameh

Last Name

Rizk

MiddleName

-

Affiliation

Department of Organic Chemistry, Faculty of Science, University of Ain Shams

Email

samehrizk@sci.asu.edu.eg

City

CAIRO

Orcid

0000-0002-8232-5399

First Name

Fakhri

Last Name

El-Bassiouny

MiddleName

-

Affiliation

Department of Organic Chemistry, Faculty of Science, University of Ain Shams

Email

fabassiouny121542@hotmail.com

City

CAIRO

Orcid

-

First Name

Dalal

Last Name

Guirguis

MiddleName

-

Affiliation

Department of Organic Chemistry, Faculty of Science, University of Ain Shams

Email

dalaguirguis45@yahoo.com

City

cairo

Orcid

-

First Name

Sherif

Last Name

Khairy

MiddleName

-

Affiliation

Department Of Reactor Materials , Nuclear Material Authority, Cairo, Egypt.

Email

sherifmkhiry@gmail.com

City

Cairo

Orcid

-

First Name

Laila

Last Name

Guirguis

MiddleName

-

Affiliation

Department Of Reactor Materials , Nuclear Material Authority, Cairo, Egypt.

Email

lailagargus@yahoo.com

City

cairo

Orcid

-

Volume

60

Article Issue

3

Related Issue

567

Issue Date

2017-06-01

Receive Date

2017-04-13

Publish Date

2017-06-01

Page Start

407

Page End

420

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 60_Issue 3_Pages 407-420.pdf

PDF . 1.4MB

Link

https://ejchem.journals.ekb.eg/article_3286.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=3286

Order

5

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Facile Synthesis and Structural Characterization of Some Phthalazin-1(2H)-one Derivatives as Antimicrobial Nucleosides and Reactive Dye

Details

Type

Article

Created At

22 Jan 2023