HEREIN, we represent a novel route for antibacterial finishing of cotton fabric. The novelty involves preparation of cyclodextrins based copolymers which are applied along with silver nitrate to yield silver nanoparticles (AgNPs). The latter are intermediately associated with the copolymer which is distributed in the fiber-fabric structure. In a more specific sense, the present work comprises three main studies 1) Synthesis of novel finishes based on graft copolymerization of β-cyclodextrin (β-CD) and reactive cyclodextrin (RCD) with acrylonitrile AN,2) characterization of obtained copolymers and 3) application of these copolymers along with AgNO3 to cotton fabric to ultimately create Ag NPs in the fiber-fabric structure. In the first study optimal condition of the synthesis of said copolymers were established. The second study was devoted to monitoring nitrogen content, graft yield percent and grafting efficiency percent. The third study emphasized the application of the copolymer in presence of silver nitrate which is converted to AgNPs under the copolymer dual reducing and stabilizing action. The copolymers containing AgNPs were embedded within the cotton fabric and imparted to it thermal stability along with antibacterial properties .It was also found that using RCD as a base for copolymerization with AN displays higher effects in terms of nitrogen content, graft yield, than β-CD.