Synthesis and Tranquilizing Effect of New Dibenzoxazepines and Pyridobenzoxazepines - Egyptian Knowledge Bank

1435

Synthesis and Tranquilizing Effect of New Dibenzoxazepines and Pyridobenzoxazepines

Article

Last updated: 01 Jan 2025

Subjects

Abstract

ASERIES of new 6,7,8,9-tetrahydrodibenz[ b,f][1,4]oxazepin-11(10H)-ones (3) was prepared by alkylation of salicylamides 1 with 2-chlorocyclohexanone followed by cyclodehydration of the resulting 2-cyclohexyloxybenzamides 2. New pyrido [2,3-b] [1,4]benzoxazepin-6(5H)-ones (8) were prepared by reacting salicoyl chlorides 4 or their corresponding acids 5 with 3-amino-2-chloropyridines 6 followed by treatment of the resulting amides 7 with sodium methoxide. Some of the new compounds were subjected to preliminary screened for their tranquilizing effect.

DOI

10.21608/ejchem.2011.1435

Keywords

Dibenz[b, f][1, 4]oxazepin-11(10H)-ones, Pyrido [2, 3-b] [1, 4] benz- oxazepin-6(5H)-ones, Tranquilizers and Diazepam

Volume

Article Issue

Related Issue

307

Issue Date

2012-10-01

Receive Date

2011-11-27

Publish Date

2011-12-31

Page Start

691

Page End

701

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 54_Issue 5_Pages 691-701.pdf

PDF . 304.6kB

Link

https://ejchem.journals.ekb.eg/article_1435.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=1435

Order

Type Code

292

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle