Antimicrobial Activities of Some Novel Synthesized Aryl-pyrazole, Isoxazole, Pyran and Pyridine Derivatives from 3-Aryl-1- (2-naphthyl) Prop-2-en-1-ones - Egyptian Knowledge Bank

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Antimicrobial Activities of Some Novel Synthesized Aryl-pyrazole, Isoxazole, Pyran and Pyridine Derivatives from 3-Aryl-1- (2-naphthyl) Prop-2-en-1-ones

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Last updated: 01 Jan 2025

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Abstract

3-ARYL-1-(2-naphthyl)prop-2-en-1-ones (1) were reacted with .......hydrazine hydrate, phenyl hydrazine, hydroxylamine hydrochloride as nitrogen nucleophiles and with malononitrile, cyclohexanone, cyclopentanone as carbon nucleophiles to afford the corresponding dihydropyrazole 2,3and isoxazole 4 derivatives successively. Furthermore, cyanoamino pyran 5 and cyanoamino pyridine 6 derivatives were obtained. Additionally, a novel series of 1,5- diketone derivatives 7 and 8 were obtained, synthesized by base catalysed addition of cyclohexanone or cyclopentanone to compound 1. The latter compounds 7 and 8 were reacted with hydrazine hydrate to afford the respective hydrazide 9 and 10. Some of these compounds have been screened for antimicrobial activities. The structure assignments are based on the analytical and spectroscopic results.

DOI

10.21608/ejchem.2011.1429

Keywords

α, β-Unsaturated ketones, 1, 5-Diketones, Nicotinonitriles, pyrazole, Isoxazole, Pyran and pyridine derivatives and Antimicrobial activity

Volume

Article Issue

Related Issue

307

Issue Date

2012-10-01

Receive Date

2011-11-27

Publish Date

2011-10-31

Page Start

609

Page End

622

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 54_Issue 5_Pages 609-622.pdf

PDF . 411.3kB

Link

https://ejchem.journals.ekb.eg/article_1429.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=1429

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Type Code

292

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

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