2- (3, 4- Dimethylphenyl - 3- [3, 4-Dichloro (or 3, 4-Dimethyl) Benzoyl])-Propanoic Acids as Precursors in the Synthesis of Some Heterocyclic Compounds - Egyptian Knowledge Bank

1427

2- (3, 4- Dimethylphenyl - 3- [3, 4-Dichloro (or 3, 4-Dimethyl) Benzoyl])-Propanoic Acids as Precursors in the Synthesis of Some Heterocyclic Compounds

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Last updated: 01 Jan 2025

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Abstract

3-(3,4-DICHLORO (or 3,4-dimethyl)benzoyl)] prop-2-enoic acids 1 ..... react with o-xylene and p-xylene under Friedel-Craft's reaction conditions giving acids 2 or 3, respectively. They were converted into the corresponding pyridazinone 4 derivatives upon treatment with N2H4 in boiling ethanol . The pyridazine derivatives 9,10,11 can be synthesized as a pro-drug due to their more potent and less peripheral effects than non-acidic or weakly acidic NSAIDs. Also, triazolopyridazine, oxazinone and furanone were also investigated.

DOI

10.21608/ejchem.2012.1427

Keywords

3-Aroylprop-2- enoic acids, Pyridazinone, Triazolopyridazine, furanone, Pyridine, Oxime and Oxazinone

Volume

Article Issue

Related Issue

307

Issue Date

2012-10-01

Receive Date

2011-03-06

Publish Date

2012-10-01

Page Start

579

Page End

593

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 54_Issue 5_Pages 579-593.pdf

PDF . 307.8kB

Link

https://ejchem.journals.ekb.eg/article_1427.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=1427

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Type Code

292

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

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