Synthesis and Tranquillizing Effect of New 1,4-Benzoxazepines - Egyptian Knowledge Bank

1411

Synthesis and Tranquillizing Effect of New 1,4-Benzoxazepines

Article

Last updated: 22 Jan 2023

Subjects

Abstract

SAERIES of new 1,4-benzoxazepin-5(4H)-ones was prepared by …….alkylation of salicylamides with phenacyl bromides followed by cyclodehydration of the resulting amides. Treatment of the 1,4-benzoxazepine-5(4H)-ones with phosphorus pentasulphide afforded the corresponding 1,4-benzoxazepine-5(4H)-thiones. N-alkylation of the 1,4- benzoxazepin-5(4H)-ones and S-alkylation of the 1,4-benzoxazepine-5(4H)-thiones were described. Some of the new compounds were subjected to preliminary screening for their tranquilizing effect.

DOI

10.21608/ejchem.2011.1411

Keywords

4-Benzoxazepin-5(4H)-ones, 1, 4-Benzoxazepine-5(4H)-thiones, N-alkylation, S- alkylation, Tranquilizers and Diazepam

Volume

Article Issue

Related Issue

306

Issue Date

2012-08-01

Receive Date

2011-09-27

Publish Date

2011-10-31

Page Start

565

Page End

578

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 54_Issue 4_Pages 565-578.pdf

PDF . 323.1kB

Link

https://ejchem.journals.ekb.eg/article_1411.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=1411

Order

Type Code

292

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Details

Type