New Pyridone, Furopyridine and Pyrazolo-pyridine Derivatives Bearing 5,6,7,8-Tetrahy-dronaphthalene Moiety: Synthesis, Antimicrobial and Genotoxicity Evaluation - Egyptian Knowledge Bank

1408

New Pyridone, Furopyridine and Pyrazolo-pyridine Derivatives Bearing 5,6,7,8-Tetrahy-dronaphthalene Moiety: Synthesis, Antimicrobial and Genotoxicity Evaluation

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Last updated: 01 Jan 2025

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Abstract

REACTIONof 2-acetyl-5,6,7,8-tetrahydronaphthalene (1) with different aromatic aldehydes yielded the corresponding cyanopyridone derivatives 2a,b. Upon heating of 2a with chloroacetone, led to the formation of furopyridine derivative 4, while the reaction of compounds 2a,b with ethyl bromoacetate afforded 3–cyanopyridinyl derivatives 5a, b. Condensation of 5a,b with different amines gave the compounds 6a, b, 7 or 8a, b, respectively. Pyrazolopyridine derivatives 9a, b, 10a, b, 11 were obtained upon the reaction of compound 8a with different aromatic aldehydes, ketones and/or substituted malononitrile. The antimicrobial activity evaluation exhibited that 7, 10a,b are promising antibacterial and antifungal agents. Genotoxicity evaluation indicated that both 2a, 8a produced a protection against cytogenetic changes induced by cyclophosphamide in mice.

DOI

10.21608/ejchem.2011.1408

Keywords

pyridone, Furopyridine, Pyridine, Pyrazolopyridine and Genotoxicity

Volume

Article Issue

Related Issue

306

Issue Date

2012-08-01

Receive Date

2011-11-13

Publish Date

2011-10-31

Page Start

509

Page End

532

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 54_Issue 4_Pages 509-532.pdf

PDF . 646.5kB

Link

https://ejchem.journals.ekb.eg/article_1408.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=1408

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Type Code

292

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

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