Sythesis of Some New Quinazolin-4-one Derivatives - Egyptian Knowledge Bank

1402

Sythesis of Some New Quinazolin-4-one Derivatives

Article

Last updated: 01 Jan 2025

Subjects

Abstract

TREATMENT of 3,4-dihydroquinazolin-4-one (2a) with P2S5 ……..yielded the corresponding thione 3 that treated with hydrazine/or 2-aminoethanol afforded quinazoline derivatives 4.The hydrazinoquinazoline 4b converted to (sulphahydryl and/or methyl) triazoloquinazoline via interaction with CS2 and Ac2O. On the other hand, compound 2a reacts with ethyl chloroacetate yielded the ester derivative 9 which converted to the corresponding hydrazide 10 via interaction with hydrazine hydrate. Its behavior of hydrazide 10 towards carbon electrophiles, e.g., thiophene-2-carboxaldehyde, furfural, piperonal, o-anisaldehyde, phthalic anhydride, ammonium thiocyanate, acetyl acetone, Ac2O and ethyl acetoacetate afforded compounds 11-16. Also, behavior of compound 2b towards carbon electrophiles, e.g. acetic anhydride and benzoyl chloride afforded 17. A moderate activity was observed with new quinazolinone compounds 4-10 which proved to possess marked activity against E. coli, S. aureus and C. albicans. The strong activity was observed with compounds 3,11-17.

DOI

10.21608/ejchem.2011.1402

Keywords

(3H) quinazolin 4one, 1, 3, 4 Oxadiazolequinazolinone, Phthali-mido, Furan, THIOPHENE, Pyrazoloquinazoline and 1, 2, 4-Triazole quinazoline

Volume

Article Issue

Related Issue

306

Issue Date

2012-08-01

Receive Date

2011-03-06

Publish Date

2011-08-31

Page Start

411

Page End

422

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 54_Issue 4_Pages 411-422.pdf

PDF . 309.5kB

Link

https://ejchem.journals.ekb.eg/article_1402.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=1402

Order

Type Code

292

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle