New Approaches for the Uses of 2-Cyanomethyl Thiazole in the Synthesis of Fused Heterocyclic Derivatives with Anti-Tumor Activities - Egyptian Knowledge Bank

1395

New Approaches for the Uses of 2-Cyanomethyl Thiazole in the Synthesis of Fused Heterocyclic Derivatives with Anti-Tumor Activities

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Last updated: 22 Jan 2023

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Abstract

2-(4,5-DIHYDRO-4-oxothiazol-2-yl)acetonitrile (1) reacted with 2- .......acetylcoumarin (2) to give the 2-(4,5-dihydro-4-oxothiazol-2-yl)- 3-(2-oxo-2H-chromen-3-yl)but-2-enenitrile (3). The reactivity of the latter product towards aromatic aldehydes 4a-d, cyanomethylene reagents 6a,b, aryl diazonium salts 10a-d, was studied to give products that were evaluated against the three cancer cells namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268). Some of them have high inhibitory effect towards three cell lines and compounds 14 and 16 were found to be more active than the standard on NCI-H460 and SF-268.

DOI

10.21608/ejchem.2011.1395

Keywords

thiazole, Coumarin, pyrazole, Pyridazine and Anti-tumor

Volume

Article Issue

Related Issue

304

Issue Date

2012-04-01

Receive Date

2011-08-22

Publish Date

2011-04-30

Page Start

289

Page End

297

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 54_Issue 2_Pages 289-297.pdf

PDF . 296.6kB

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https://ejchem.journals.ekb.eg/article_1395.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=1395

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Type Code

292

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Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

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