ASERIES of anionic surface active agents were prepared from salicylic acid by esterification with fatty alcohols (Ia-i) [decyl C10: 0 , dodecyl C1: 0, tetradeyl C14 : 0, hexadecyl C16 : 0, octdecyl C18 : 0 , octdec 9-enyl C18 : 1, octdec 9,12-dienyl C18 : 2 , mixed fatty alcohol of Juagafa seed fat and mixed fatty alcohols of Grape oil ], in the presence of p-toluene sulfonic acid as catalyst , forming an alkyl salicylates [IIa-i], which are converted to anionic sulfated, sulfonated fatty alkyl salicylate [IVa-i). Also, the prepared esters (IIa-i) were oxypropylated with various unit of propylene oxide (2, 4 and 6 moles) to give (IIIa-i). These compounds were converted to a modified anionic surfactants (Va-i) as molecular aggregations and surface active agents in aqueous media. These derivatives were purified and characterized by micro-analysis, IR and 1H-NMR spectra studies. Also, surface activity, and biodegradability were evaluated. The improved synthesized anionic surface active agents with propylene oxide, from commercial grape oil and or juagafa fat revealed good surface activities such as surface and interfacial tension, lower TK.p , high foam height, good tolerance toward hard water, higher stability towards basic media and high biodegradable compounds. This situation focused our attention to utilize an economic low priced sources for preparation of surface active compounds with high important applications in industrial field and decease the environmental pollution .