Physicochemical Characterization of Solid Norfloxacin and Ciprofloxacin Metal Complexes: Spectroscopic and Thermal Studies - Egyptian Knowledge Bank

1391

Physicochemical Characterization of Solid Norfloxacin and Ciprofloxacin Metal Complexes: Spectroscopic and Thermal Studies

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Last updated: 01 Jan 2025

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Abstract

SPECTROSCOPIC methods such as mass, infrared, nuclear magnetic resonance and X-ray diffraction in combination with thermal measurements are used to monitor and describe the physicochemical properties of the solid drug substances; the novel nor- and ciprofloxacin chromium(III) and zirconium (IV) metal complexes. The results support the formation of complexes with the formula [Cr(Nor)2](NO3)3.4 H2O, [Cr (Cip)2].7H2O, [Zr (Nor)2].3.5 H2O and [Zr (Cip)2].5H2O. The FT/IR spectra of the isolated complexes suggest that norfloxacin and ciprofloxacin act as bidentate ligands through the ring carbonyl oxygen atom and one of the oxygen atoms of the carboxylic group. Thermal studies indicate that the complexes dehydrate at lower temperatures followed by pyrolytic decomposition at higher temperatures and the results show that zirconium complexes are more stable than chromium complexes.

DOI

10.21608/ejchem.2011.1391

Keywords

ciprofloxacin, Norfloxacin, Spectroscopy and Thermal analysis

Volume

Article Issue

Related Issue

304

Issue Date

2012-04-01

Receive Date

2011-07-27

Publish Date

2011-04-30

Page Start

239

Page End

256

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 54_Issue 2_Pages 239-256.pdf

PDF . 811.8kB

Link

https://ejchem.journals.ekb.eg/article_1391.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=1391

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Type Code

292

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

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