IN CONECTION with our previous interest in developing new .....approaches for synthesis of heterocyclic utilizing readily obtainable starting materials, we reported here synthesis of a new heterocyclic utilizing 1-acetyl naphthalene. Reaction of acetyl naphthaline with phenyl hydrazine, thiosemicarbazide and hydroxylamine was carried out to give compounds 1,2,5, respectively. Under claisen condensation acetyl naphthalene reacted with ethylacetoacetate to give acetonaphthoyl keton 3 which converted to pyrazoline derivative 4 by reaction with hydrazine hydrate. On the other hand when acetyl naphthalene reacted with 4-chloro benzaldhyde afforded the chalcone derivative 7, which reacted with hydroxylamine, bromine, hydrazine hydrate and hydrogen peroxide a to give compounds 8, 9, 10, 11, respectively . The newly synthesized compounds were tasted as anti-microbial activity .