Synthesis and Biological Evaluation of Some New Naphthyl Derivatives as Anti-microbial Activity - Egyptian Knowledge Bank

1384

Synthesis and Biological Evaluation of Some New Naphthyl Derivatives as Anti-microbial Activity

Article

Last updated: 01 Jan 2025

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Abstract

IN CONECTION with our previous interest in developing new .....approaches for synthesis of heterocyclic utilizing readily obtainable starting materials, we reported here synthesis of a new heterocyclic utilizing 1-acetyl naphthalene. Reaction of acetyl naphthaline with phenyl hydrazine, thiosemicarbazide and hydroxylamine was carried out to give compounds 1,2,5, respectively. Under claisen condensation acetyl naphthalene reacted with ethylacetoacetate to give acetonaphthoyl keton 3 which converted to pyrazoline derivative 4 by reaction with hydrazine hydrate. On the other hand when acetyl naphthalene reacted with 4-chloro benzaldhyde afforded the chalcone derivative 7, which reacted with hydroxylamine, bromine, hydrazine hydrate and hydrogen peroxide a to give compounds 8, 9, 10, 11, respectively . The newly synthesized compounds were tasted as anti-microbial activity .

DOI

10.21608/ejchem.2011.1384

Volume

Article Issue

Related Issue

303

Issue Date

2012-02-01

Receive Date

2011-04-12

Publish Date

2011-02-28

Page Start

129

Page End

139

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 54_Issue 1_Pages 129-139.pdf

PDF . 681.3kB

Link

https://ejchem.journals.ekb.eg/article_1384.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=1384

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Type Code

292

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

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