Synthesis and Biological Activity of Some New Substituted Quinazolin-4(3H)-Ones - Egyptian Knowledge Bank

1376

Synthesis and Biological Activity of Some New Substituted Quinazolin-4(3H)-Ones

Article

Last updated: 22 Jan 2023

Subjects

Abstract

3- (4-AMINOPHENYL)-2-benzyl-4-oxo-3,4-dihydroquinazoline 1a and 3 - (4 - aminophenyl) - 2 - benzyl - 6 - bromo - 4 - oxo -3, 4 dihydroquinazoline 1b were prepared and diazotized by nitrous acid to give ″2a, b″. The diazonium chloride derivatives were converted to the corresponding 3-arylhydrazono derivatives on treatment with active methylene compounds namely acetylacetone, ethyl acetoacetate and/or ethyl cyanoacetate. The hydrazono derivatives were converted to the corresponding pyrimidino derivatives ″6a-f″, pyrazolo derivatives ″7a-d″ and pyrazoline derivatives ″8a-d″ and ″9a-f″ in order to study their antimicrobial activity. A significant level of activity of the new products was observed.

DOI

10.21608/ejchem.2011.1376

Keywords

2- Benzyl - 4(3H) quinazolinone - 4 - (3H) - one, 6-Bromo derivative, Aryl hydrazones, β-Diketones and Biological activity

Volume

Article Issue

Related Issue

303

Issue Date

2012-02-01

Receive Date

2010-07-13

Publish Date

2011-02-28

Page Start

Page End

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 54_Issue 1_Pages 1-15.pdf

PDF . 492.5kB

Link

https://ejchem.journals.ekb.eg/article_1376.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=1376

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Type Code

292

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

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Details

Type