Effect of Refining Processes on Magnitude and Nature of Fenitrothion and Pirimiphos-Methyl Residues in Maize Oil and Bioavailability of their Cake Residues on Rats* - Egyptian Knowledge Bank

1271

Effect of Refining Processes on Magnitude and Nature of Fenitrothion and Pirimiphos-Methyl Residues in Maize Oil and Bioavailability of their Cake Residues on Rats*

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Last updated: 01 Jan 2025

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Abstract

MAIZE seeds obtained from 14C-fenitrothion or 14C-pirimiphos-methyl treated maize plants contained about 0.12 % and 0.16 % of the originally applied radioactivity, respectively. The concentration of 14C-fenitrothion residues and 14C-pirimiphos-methyl residues in crude oil (hexane extract) ranged from 2.8-3.0 ppm, methanol solubles 2.3 ppm and in seed cake 1.2-1.4 ppm. Commercial processing procedures led to a gradual decrease in the total amount of 14C-residues in oils with aged residues. The refined oil contained only about 13-19% of the radioactivity originally present. The deodorization and alkali treatment are the most effective steps as they removed over 50 % of the residues. Chromatographic analysis of refined oil revealed the presence of fenitrothion, 3-methyl-4-nitrophenol as main products beside smaller amounts of fenitrooxon and desmethyl fenitrothion. Whereas, pirimiphos-methyl and 2-diethyl-2-amino-4-hydroxy-6-methylpyrimidine were detected as principal compounds together with minor amounts of 2-ethyl-amino-4-hydroxy-6-methylpyrimidine and 2-amino-4-hydroxy-6-methyl-pyrimidine. On feeding rats with the extracted seeds (cake) for three days, the bound residues were found to be considerably bioavailable. A substantial amount of administrated bound 14C-residues was eliminated via respiration (50%) for 14C-fenitrothion and excreted urine (47%) for 14C-pirimiphos-methyl. While feces contained only 10-12% and about 22-26% of the radioactive residues were distributed among various organs of experimental animals.

DOI

10.21608/ejchem.2010.1271

Keywords

14C-Fenitrothion, 14C-Pirimiphos-methyl, Maize seed oil, Insecticide residues, Refining processes and Bioavailability

Volume

Article Issue

Related Issue

293

Issue Date

2010-12-01

Receive Date

2010-12-22

Publish Date

2010-12-31

Page Start

923

Page End

938

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 53_Issue 6_Pages 923-938.pdf

PDF . 435.3kB

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https://ejchem.journals.ekb.eg/article_1271.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=1271

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Type Code

292

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Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

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