Synthesis and Biological Evaluation of Some New 4(3h)-Quinazolinone Derivatives as Non-Classical Antifolate - Egyptian Knowledge Bank

1263

Synthesis and Biological Evaluation of Some New 4(3h)-Quinazolinone Derivatives as Non-Classical Antifolate

Article

Last updated: 22 Jan 2023

Subjects

Abstract

ALL living cell need tetrahydrofolate cofactor for the synthesis of ........ purines, some amino acid and thymidine. Most bacteria and plant produce this folate cofactor by de novo biosynthesis. Compounds that interfere with this pathway, antifolate agents have found use as anticancer. Thus, the 2-propyl-4H-3,1-benzoxazin-4-one (2) was synthesized and allowed to interaction with Ammonium acetate or formamide afforded -2- propylquinazolin-4(3H)-one (3). Behaviour of quinazolinone towards carbon electrophiles namely, aromatic aldehyde, chloroacetylchloride, and ethylchloroacetate has been investigated and all the synthesized compounds were tested as anti-cancer in National Cancer Institute (NCI) in USA.

DOI

10.21608/ejchem.2010.1263

Keywords

Benzoxazin-4-one, Quinazolin-4(3H) one and Anthranil

Volume

Article Issue

Related Issue

293

Issue Date

2010-12-01

Receive Date

2010-01-31

Publish Date

2010-12-31

Page Start

777

Page End

790

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 53_Issue 6_Pages 777-790.pdf

PDF . 395.9kB

Link

https://ejchem.journals.ekb.eg/article_1263.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=1263

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Type Code

292

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Details

Type