Synthesis of New Pyrazolones and Fused Pyrazole Derivatives as Antimicrobial Agents - Egyptian Knowledge Bank

1261

Synthesis of New Pyrazolones and Fused Pyrazole Derivatives as Antimicrobial Agents

Article

Last updated: 22 Jan 2023

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Abstract

SOME new pyrazolone and fused pyrazole derivatives start ……from enaminone-type precursor. This approach constitutes a novel and advantageous alternative for the synthesis of the target heterocycles. Thus, the reaction of pyrazolone 1 and DMFDMA afforded 4-(dimeth-ylamino)methylidenepyrazol-3-one (2). Enaminone 2 was utilized as a key intermediate for the synthesis of new pyrazolones 8, 9, 12, and 14, fused pyrazolones 4-7, and 10 and the spiro adducts 15a, b. The antimicrobial activity of some of the newly synthesized adducts were evaluated against six strains of Gram positive, Gram negative and fungi in comparison with Ampicillin and Nystatine.

DOI

10.21608/ejchem.2010.1261

Keywords

Pyrazolones, Pyrazoloisoxazole, Pyrazolopyrazole, Pyrazoloquinoline, Pyrazoloenaminone, antimicrobial activity

Volume

Article Issue

Related Issue

292

Issue Date

2010-10-01

Receive Date

2010-02-14

Publish Date

2010-10-31

Page Start

731

Page End

744

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 53_Issue 5_Pages 731-744.pdf

PDF . 557.5kB

Link

https://ejchem.journals.ekb.eg/article_1261.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=1261

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Type Code

292

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

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Details

Type