Synthesis , Reactions and Antimicrobial Activity on Some Novel Phthalazinone Derivatives - Egyptian Knowledge Bank

1255

Synthesis , Reactions and Antimicrobial Activity on Some Novel Phthalazinone Derivatives

Article

Last updated: 22 Jan 2023

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Abstract

ASIMPLE and efficient synthesis of [4-(3, 4-dimethylphenyl)-5, 6, 7, 8-tetrabromo-1-oxo-1H-phthalazin-2-yl]-acetic acid hydrazide (IV) has been carried out. The obtained hydrazide (IV) has been used in synthesis of some interesting heterocycles such as pyrazolone, thiazolidinone, pyrimidine, benzoxazine lactam, rhodanine, quinazoline and benzoxazinone (VIII –XVII). Some of the prepared compounds tested for in vitro antibacterial activities. Among those tested, many compounds showed good antibacterial activities.

DOI

10.21608/ejchem.2010.1255

Keywords

Phthalazinone, pyrazolone, thiazolidinone, Azitidinone, Quinazoline, Pyrimidine derivatives and Antimicrobial activity

Volume

Article Issue

Related Issue

292

Issue Date

2010-10-01

Receive Date

2010-04-26

Publish Date

2010-10-31

Page Start

645

Page End

660

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 53_Issue 5_Pages 645-660.pdf

PDF . 436.3kB

Link

https://ejchem.journals.ekb.eg/article_1255.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=1255

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Type Code

292

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

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Details

Type