ASIMPLE, accurate and sensitive kinetic spectrophotometric method is …. described for analysis of cefprozil and dropropizine. The method is based on kinetic investigations of the oxidation reaction of the drugs with alkaline potassium permanganate (KMnO4) at room temperature. The reaction is monitored spectrophotometrically by measuring the rate of change of absorbance of the resulting manganate species at 610 or 608 nm for cefprozil or dropropizine, respectively, with time. The two calibration curves at fixed-time method for the two drugs are utilized for the assay of drugs in the concentration ranges of 1.0-8.0 and 0.2-2.0 g ml-1 for cefprozil and dropropizine, respectively. The results are optimized and validated statistically and through recovery studies. The method has been successfully applied to the determination of cefprozil and dropropizine in pharmaceutical preparations. The results obtained are compared statistically with those given by the reference method. A proposal of the oxidation reaction pathway is postulated.