A Sensitive Kinetic Spectrophotometric Determination of Cefprozil and Dropropizine in Bulk and in Dosage Forms - Egyptian Knowledge Bank

1254

A Sensitive Kinetic Spectrophotometric Determination of Cefprozil and Dropropizine in Bulk and in Dosage Forms

Article

Last updated: 01 Jan 2025

Subjects

Abstract

ASIMPLE, accurate and sensitive kinetic spectrophotometric method is …. described for analysis of cefprozil and dropropizine. The method is based on kinetic investigations of the oxidation reaction of the drugs with alkaline potassium permanganate (KMnO4) at room temperature. The reaction is monitored spectrophotometrically by measuring the rate of change of absorbance of the resulting manganate species at 610 or 608 nm for cefprozil or dropropizine, respectively, with time. The two calibration curves at fixed-time method for the two drugs are utilized for the assay of drugs in the concentration ranges of 1.0-8.0 and 0.2-2.0 g ml-1 for cefprozil and dropropizine, respectively. The results are optimized and validated statistically and through recovery studies. The method has been successfully applied to the determination of cefprozil and dropropizine in pharmaceutical preparations. The results obtained are compared statistically with those given by the reference method. A proposal of the oxidation reaction pathway is postulated.

DOI

10.21608/ejchem.2010.1254

Keywords

Cefprozil, Dropropizine, potassium permanganate, Kinetic spectrophotometry and Pharmaceutical analysis

Volume

Article Issue

Related Issue

292

Issue Date

2010-10-01

Receive Date

2010-02-09

Publish Date

2010-10-31

Page Start

631

Page End

643

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 53_Issue 5_Pages 631-643.pdf

PDF . 403.8kB

Link

https://ejchem.journals.ekb.eg/article_1254.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=1254

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Type Code

292

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle