Synthesis and Conformational Analysis of Some Erythropoietin Mimetic Peptides Using Microwave Energy - Egyptian Knowledge Bank

1233

Synthesis and Conformational Analysis of Some Erythropoietin Mimetic Peptides Using Microwave Energy

Article

Last updated: 22 Jan 2023

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Abstract

THE CURRENT study describes the synthesis of Erythropoietin- ......which is a prohibited hormone by WADA-mimetic peptides [(AFIII54(chain I), (Ser)12AFIII54(chain II), AFIII54 with addition of Gly and Tyr in position 4 and 5, respectively (chain VI), AFIII54 devoid (Thr)9 and )Trp)10 (chain VII), (EMP3(chain III),(Ser)15EMP3 (chain IV), (Ala)15EMP3(chain V), EMP3 with addition of Gly and Tyr in position 7 and 8, respectively (chain VIII) and EMP3 devoid (Thr)12and (Trp)13(chain IX) ] by SPPS using microwave energy which accelerated reaction rate and improved the purities and yield. Conformational analysis using FT-IR spectroscopy showed that most the synthesised peptides existed in α-helix structure . Also, biological activity for one of these sequences was studied.

DOI

10.21608/ejchem.2010.1233

Keywords

erythropoietin, Mimetic peptides, Synthesis and Microwave conformational analysis

Volume

Article Issue

Related Issue

290

Issue Date

2010-06-01

Receive Date

2010-06-22

Publish Date

2010-06-30

Page Start

435

Page End

448

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 53_Issue 3_Pages 435-448.pdf

PDF . 664.4kB

Link

https://ejchem.journals.ekb.eg/article_1233.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=1233

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Type Code

292

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

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Details

Type