Synthesis of New Bithiophene and Thieno [2,3-d] Pyrimidine Derivatives with Potent Antimicrobial Activity - Egyptian Knowledge Bank

1229

Synthesis of New Bithiophene and Thieno [2,3-d] Pyrimidine Derivatives with Potent Antimicrobial Activity

Article

Last updated: 01 Jan 2025

Subjects

Abstract

THE VERSATILE synthon 2-Amino-4-(thiophene-2-yl) thiophene-3-carbonitrile (1) was used as precursor for the synthesis of a series of bithiophene (2) and thieno [2, 3-d] pyrimidine (3) derivatives. The antimicrobial evaluations of the newly synthesized compounds were carried out in vitro assays for antifungal and antibacterial activities. Amongst the tested compounds, 1-(4\-cyano-2,3\-bithiophen-5\-yl)3-phenylthiourea (2b), 4-imino-3-phenyl-5-(thiophenyl-2-yl)-3,4-dihydrothieno[2,3-d] pyrimidine-2(1H)-thione (3b) and 1-phenyl-3-(5-(thiophenyl-2-yl)thieno[2,3-d]pyrimidin-4-yl) thiourea (5c) exhibit significant antibacterial activities against Pseudomonas sp, Escherichia coli, Streptococcus lactis, Bacillus subtilis and exhibit significant antifungal activities against Aspergillus niger, Penicillium sp, Candida albicans and Rhodotorula ingeniosa. From structure-activity relationship (SAR) point of view, the attachment of phenyl thioureido moiety to bithiophenes can be considered as a breakthrough in developing a new therapeutic antimicrobial agents related to bithiophene system.

DOI

10.21608/ejchem.2010.1229

Keywords

Phenylthiourea, Bithiophen, Heterocycles, Antimicrobial agents, Structure elucidation and Thieno [2, 3-d] pyrimidine

Volume

Article Issue

Related Issue

290

Issue Date

2010-06-01

Receive Date

2010-04-12

Publish Date

2010-06-30

Page Start

385

Page End

401

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 53_Issue 3_Pages 385-401.pdf

PDF . 761.2kB

Link

https://ejchem.journals.ekb.eg/article_1229.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=1229

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Type Code

292

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

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