Design and Synthesis of Peptide Derivatives Act as DNA Binding Agent and Discovery of Potent Carbonic Anhydrase Inhibitors Using Docking Studies - Egyptian Knowledge Bank

1221

Design and Synthesis of Peptide Derivatives Act as DNA Binding Agent and Discovery of Potent Carbonic Anhydrase Inhibitors Using Docking Studies

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Last updated: 01 Jan 2025

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Abstract

NEW peptide series of 2-(2-oxo-2H benzo[h] chromen-4-yl) acetyl ........derivatives 3-5, 15-20 and their corresponding methyl esters 6-14 were synthesized. Structures of the synthesized products were characterized by correct elemental analysis, IR, Mass and 1H-NMR spectroscopy. DNA binding activities were performed. Some synthesized compounds showed high binding affinity against DNA. Virtual screening using molecular docking studies of the synthesized compounds were performed, the molecular docking results indicate that, most of the synthesized compounds are more suitable inhibitors against carbonic anhydrase isozyme (CA) than reference drug.

DOI

10.21608/ejchem.2010.1221

Volume

Article Issue

Related Issue

289

Issue Date

2010-04-01

Receive Date

2010-03-29

Publish Date

2010-04-30

Page Start

279

Page End

299

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 53_Issue 2_Pages 279-299.pdf

PDF . 1.4MB

Link

https://ejchem.journals.ekb.eg/article_1221.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=1221

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Type Code

292

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

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