Uses of 4, 5, 6, 7-tetrahydrobenzo[b]thiophene Derivatives in Heterocyclic Synthesis: Synthesis of Pyrazol, Pyrimidine and Pyridazine Derivatives with Antimicrobial Activities - Egyptian Knowledge Bank

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Uses of 4, 5, 6, 7-tetrahydrobenzo[b]thiophene Derivatives in Heterocyclic Synthesis: Synthesis of Pyrazol, Pyrimidine and Pyridazine Derivatives with Antimicrobial Activities

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Last updated: 01 Jan 2025

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Abstract

THE 2-DAIZO-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide cou coupled with either malononitrile or ethyl cyanoacetate to give the hydrazo derivatives 4a and 4b, respectively. The latter products underwent hetero-cyclization to give pyrazole, pyrimidine and pyridazine derivatives. The antimicrobial evaluation of the newly synthesized products was measured and most of the products showed interesting activities.

DOI

10.21608/ejchem.2010.1217

Keywords

Tetrahydrobenzo[b]thiophene, pyrazole, Pyrimidine and Pyridazine

Volume

Article Issue

Related Issue

289

Issue Date

2010-04-01

Receive Date

2010-02-25

Publish Date

2010-04-30

Page Start

243

Page End

255

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 53_Issue 2_Pages 243-255.pdf

PDF . 471.8kB

Link

https://ejchem.journals.ekb.eg/article_1217.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=1217

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Type Code

292

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

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