Spectrophotometric Determination of Ornidazole, Secnidazole and Tinidazole in Pharmaceutical Preparations Based on Formation of Dyes - Egyptian Knowledge Bank

1215

Spectrophotometric Determination of Ornidazole, Secnidazole and Tinidazole in Pharmaceutical Preparations Based on Formation of Dyes

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Last updated: 01 Jan 2025

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Abstract

SIMPLE and accurate spectrophotometric method was developed for the assay of ornidazole (I), secnidazole (II) and tinidazole (III) in tablet dosage form. The method depends on the reduction of the drugs with zinc dust and hydrochloric acid followed by condensation with p-hydroxy benzaldehyede at 50 oC to produce colored chromogens having absorbance at 402 nm for drugs I, II and III. The optimum experimental conditions for the proposed method were optimized and Beer's law was obeyed in the concentration ranges of 20-300 μg ml-1 for drugs I and II 20-250 μg ml-1 for drug III. The apparent molar absorptivities of the resulting colored products were found to be 1.00x102 , 1.24x102 and 1.70x102 L mol-1 cm-1, whereas Sandell sensitivities are 4.5x10-6, 3.9x10-6 and 6.7x10-6 μg cm-2 for I, II and III, respectively. The proposed method was applied successfully for the analysis of the investigated drugs in tablet form. The results obtained were statistically compared with a reported method using the student's t -test and F-variance ratio tests.

DOI

10.21608/ejchem.2010.1215

Keywords

Ornidazole, Secnidazole, Tinidazole and P- hydroxybenzaldehyde

Volume

Article Issue

Related Issue

289

Issue Date

2010-04-01

Receive Date

2010-02-22

Publish Date

2010-04-30

Page Start

233

Page End

241

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 53_Issue 2_Pages 233-241.pdf

PDF . 435.6kB

Link

https://ejchem.journals.ekb.eg/article_1215.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=1215

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Type Code

292

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

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