Synthesis, Structural Characterization of Some Pyrazolo [3,4-d] pyrimidine Derivatives as Anti-inflammatory Agents - Egyptian Knowledge Bank

1172

Synthesis, Structural Characterization of Some Pyrazolo [3,4-d] pyrimidine Derivatives as Anti-inflammatory Agents

Article

Last updated: 01 Jan 2025

Subjects

Abstract

ASERIES of pyrimidine and fused triazolopyrimidine derivatives were newly synthesized using aminopyrazole carbonitrile 1 as a had starting material and compounds 14 and 16 are intermediates. Initially, the acute toxicity of the compounds was assayed via the determination of their LD50, and all compounds were interestingly less toxic and had lower ulcerogenic activities than Diclophenac® as a reference drug. Regarding the protection against Carrageenan induced edema; the pharmacological screening showed that compounds 17, 11, 13 and 5 have good anti-inflammatory activities comparable to the reference drug. On the other hand, in searching for COX-2 inhibitor, the inhibition of plasma prostaglandine (PGE2) for the compounds was determined and the same four compounds were found the more potent agents. The detailed synthesis, spectroscopic data, pharmacological screening and acute toxicity LD50 for the synthesized compounds were reported.

DOI

10.21608/ejchem.2012.1172

Keywords

pyrazole, Pyrimidine and Anti-inflammatory

Volume

Article Issue

Related Issue

283

Issue Date

2012-10-01

Receive Date

2012-11-04

Publish Date

2012-10-30

Page Start

529

Page End

457

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 55_Issue 5_Pages 529-457.pdf

PDF . 419.6kB

Link

https://ejchem.journals.ekb.eg/article_1172.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=1172

Order

Type Code

292

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle