Synthesis, Moleculer Docking and Anticancer Screening of Some Novel Tetrahydronaphthyl Thiazolyl Pyrazoles and other Related Derivatives - Egyptian Knowledge Bank

1166

Synthesis, Moleculer Docking and Anticancer Screening of Some Novel Tetrahydronaphthyl Thiazolyl Pyrazoles and other Related Derivatives

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Last updated: 01 Jan 2025

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Abstract

CONDENSATION of 5-amino-1-[4-(1,2,3,4-tetrahydronaphthalen-7-yl) thiazol-2-yl]-1 H-pyrazole-4-carbonitrile (3) with different reagents such as triethylorthoformate, ethyl chloroformate and/or hydroxyamine hydrochloride yielded the substituted pyrazoles 4-6. Cyclocondensation of 3 with formic acid, acetic anhydride, formamide and /or acetamide afforded the pyrimidine derivatives 8-11. Reaction of 3 with carbon disulphide, substituted isothiocynate, malononitrile, aldehydes and /or chloroacetylchloride yielded the corresponding derivatives 12-16. Also, hydrolysis of 3 with conc. sulfuric acid at different conditions gave 17 and/or 18. Docking studies of the newly prepared compounds as thymidylate synthase inhibitors have been done. Some of the newly prepared compounds were evaluated as anticancer agents against three human tumor cell lines (HCT116, HePG2, MCF7).

DOI

10.21608/ejchem.2012.1166

Keywords

Tetrahydronaphthylthiazole, pyrazole, pyrazolopyrimidine, Molecular docking, Anticancer screening, HCT116, HePG2 and MCF7

Volume

Article Issue

Related Issue

282

Issue Date

2012-08-01

Receive Date

2012-12-12

Publish Date

2012-08-30

Page Start

413

Page End

435

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 55_Issue 4_Pages 413-435.pdf

PDF . 715.5kB

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https://ejchem.journals.ekb.eg/article_1166.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=1166

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Type Code

292

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

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