Synthesis and Biological Activity of Novel Thieno [2,3-d] [1,2,4] triazolo [4,3-a] pyrimidine and Pyrazolo [3,4-c] pyrazole Derivatives - Egyptian Knowledge Bank

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Synthesis and Biological Activity of Novel Thieno [2,3-d] [1,2,4] triazolo [4,3-a] pyrimidine and Pyrazolo [3,4-c] pyrazole Derivatives

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Last updated: 01 Jan 2025

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Abstract

REACTION of hydrazonoyl halides (2a-e) with either 1,2,3,5,6,7- ..........hexahydro-4H-cyclopenta[4,5]thieno[2,3-d] pyrimidin-2, 4-dithione (1) or 2 (4- Dihydro – 5 – oxo – 3 – methyl - 1H – pyrazolo – 1 – yl ) -5,6,7,8-tetrahydrothieno[2,3-d]pyrimidin-4(3H,4H) -one (11) in the presence of sodium ethoxide in refluxing ethanol / DMF mixture afforded the cyclopenta [4,5]thieno[2,3-d]triazolo [4,3-a]pyrimidines-4-thiones (7a-d) and the phenylpyrazolo[3,4-c]pyrazolcyclopenta [4,5] thieno [2,3-d] pyrimidin-4-ones (14a-e), respectively. The mechanism of the studied reactions has been discussed and the biological activity of the products 7a-d has been evaluated.

DOI

10.21608/ejchem.2012.1142

Keywords

Hydrazonoyl halides, [1, 2, 4] Triazolopyrimidine, Rearrangement, Pyrazole and Biological activities

Volume

Article Issue

Related Issue

280

Issue Date

2012-04-01

Receive Date

2012-05-10

Publish Date

2012-04-30

Page Start

191

Page End

200

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 55_Issue 2_Pages 191-200.pdf

PDF . 339.0kB

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https://ejchem.journals.ekb.eg/article_1142.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=1142

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Type Code

292

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

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