Utility of 4-(4-Bromophenyl)-4-oxo-but-2-enoic Acid in Synthesis of Some Important Heterocyclic Compounds - Egyptian Knowledge Bank

1127

Utility of 4-(4-Bromophenyl)-4-oxo-but-2-enoic Acid in Synthesis of Some Important Heterocyclic Compounds

Article

Last updated: 22 Jan 2023

Subjects

Abstract

THE PRESENT work deals with the generation and synthesis of different heterocycles via the treatment of 3-(4-bromobenzoyl) prop-2-enoic acid (1) with thiourea, ethylcyanoacetate malononitrile & acetylacetone in presence of amm.acetate and / or piperidine , 2-amino-5-phthalimidomethy l1,3,4-thiadiazole, methyl thioglycolate 4-bromoaniline and ethylacetoacetate to afford Michael and aza-Michael adduct that cyclized by hydroxyl amine and hydrazine hydrate, respectively. Additionally, utility of 2-(2-amino-5-phthalimidomethyl 1,3,4-thiadiazol-2-yl)-4-(4-bromophenyl)-4-oxo-butanoic acid (4) as a key starting material to synthesize some important heterocycles include fused oxoimidazolo [2,3-b]-1,3,4-thiadiazole.

DOI

10.21608/ejchem.2012.1127

Keywords

4-Bromophenyl-4-oxo-2-butenoic acid, Pyridine, Pyrimidine, Phthalazinhydrazone, Benzisoxazolone, Phthalimide, Thiadiazole imidazolothiadiazole and Pyridazinone

Volume

Article Issue

Related Issue

279

Issue Date

2012-02-01

Receive Date

2011-03-06

Publish Date

2012-02-28

Page Start

Page End

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 55_Issue 1_Pages 1-13.pdf

PDF . 279.5kB

Link

https://ejchem.journals.ekb.eg/article_1127.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=1127

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Type Code

292

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

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Details

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