SILVER nanoparticles (AgNPs) were synthesized as colloidal solution using Moringa oleifera extract (ME) as reducing and stabilizing agents.  The prepared AgNPs solution was applied onto cotton fabrics to impart them antimicrobial properties.  The obtained AgNPs were characterized as per world class analysis, exemplified by ultra-visible (UV-vis) spectra and Transmission Electron Microscope (TEM) for its shape and size determination. Application of these AgNPs to cotton fabrics  and evaluation of the treated fabric were done by monitoring morphological change of the fabric through Scanning Electron Microscope (SEM), also investigated towards antimicrobial and physical properties.