Synthesis of Some Amino Acid and Peptide Conjugates and their Evaluation as Potential Anti-allergic and Anti-inflammatory Agents - Egyptian Knowledge Bank

1120

Synthesis of Some Amino Acid and Peptide Conjugates and their Evaluation as Potential Anti-allergic and Anti-inflammatory Agents

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Last updated: 01 Jan 2025

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Abstract

ANEW series of N-3-(2-furanyl) acryloyl, N-3-(5-methyl)-2- ……(furanyl)-acryoyl amino acids, peptide and piprazines amids, were structurally designed and synthesized. About 23 compounds (5a-w) were synthesized and their anti-allergic and anti-inflamatory activities were evaluated relative to those of Loratadine (Clorinix®) and Diclofenac®. All the obtained products showed good anti-allergic activities with the greatest activities recorded for compounds (5g, 5h, 5j, 5k, 5m, 5n, 5v and 5w). All compounds showed LD50 with safety margin. On the other hand most compounds have no anti-inflamatory activities except products (5d, 5e and 5p).

DOI

10.21608/ejchem.2013.1120

Keywords

3-(2-Furanyl)acrylic acid, Amino acids, Piprazines and Anti-allerg and Anti-inflammatory

Volume

Article Issue

Related Issue

268

Issue Date

2013-12-01

Receive Date

2013-11-17

Publish Date

2013-12-30

Page Start

401

Page End

415

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 56_Issue 5_Pages 401-415.pdf

PDF . 465.9kB

Link

https://ejchem.journals.ekb.eg/article_1120.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=1120

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Type Code

292

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

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