Efficient Synthesis of Biopertinent Dihydropyrimidine (thi) one Derivatives via Three-component One-pot Synthesis Catalyzed by Tetrachlorosilane - Egyptian Knowledge Bank

1114

Efficient Synthesis of Biopertinent Dihydropyrimidine (thi) one Derivatives via Three-component One-pot Synthesis Catalyzed by Tetrachlorosilane

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Last updated: 01 Jan 2025

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Abstract

SERIES of dihydropyrimidine(thi)one derivatives were prepared, in …..good yields at room temperature by using a modified Biginelli reaction. The products were obtained through a one-pot three-component coupling of β-diketones, aldehydes and urea (or thiourea) in the presence of a catalytic amount of tetrachlorosilane (TCS). The effect of catalyst type, molar ratios of reactants and solvent type were also investigated; best results were obtained when TCS was employed as a catalyst and CH2Cl2 as a solvent at room temperature.

DOI

10.21608/ejchem.2013.1114

Keywords

Three-component, Dihydropyrimidinones, Biginelli reaction and Tetrachlorosilane

Volume

Article Issue

Related Issue

267

Issue Date

2013-08-01

Receive Date

2013-11-06

Publish Date

2013-08-30

Page Start

291

Page End

305

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 56_Issue 4_Pages 291-305.pdf

PDF . 513.2kB

Link

https://ejchem.journals.ekb.eg/article_1114.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=1114

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Type Code

292

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

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