Solid Phase Peptide Synthesis of Some Analogs of Bradykinin Hormone Using Microwave Energy Application (part II) - Egyptian Knowledge Bank

1104

Solid Phase Peptide Synthesis of Some Analogs of Bradykinin Hormone Using Microwave Energy Application (part II)

Article

Last updated: 22 Jan 2023

Subjects

Abstract

THREE analogs of Bradykinin, (Cys6,8) BK, (Cys2,5) BK and (Cys1,9) BK were synthesized by modified solid phase peptide synthesis with the application of microwave energy. The effect of the replacement of; Ser6 and Phe8 by Cys6,8, Pro2 and Phe5 by Cys2,5,and Arg1,9 by Cys1,9 on the biological activity of bradykinin was investigated. A continued work of a previously done study includes synthesis of three BK analogs, (Lys1) BK, (Lys9) BK and (Lys1, 9) BK, using the modified solid phase peptide synthesis with microwave energy. The six analogues have been tested in vitro for their effect on heart rate and in isolated organ for the arterial pressure of rats.

DOI

10.21608/ejchem.2013.1104

Keywords

Bradykinin, Modified solid phase peptide synthesis and Microwave energy

Volume

Article Issue

Related Issue

265

Issue Date

2013-04-01

Receive Date

2013-04-08

Publish Date

2013-04-30

Page Start

141

Page End

153

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 56_Issue 2_Pages 141-153.pdf

PDF . 520.3kB

Link

https://ejchem.journals.ekb.eg/article_1104.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=1104

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Type Code

292

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Details

Type