IN the last few decades, a lot of work has been done on thiazole ….derivatives due to their versatile utility associated with them. Thiazole derivatives have been reported to exhibit biological activity and are widely used as pharmaceuticals. In this research, a series of thiazole derivatives were prepared, the structures of the products were established by elemental analysis, FTIR, 1H NMR and mass spectroscopy. The prepared thiazole derivatives A, B and C, were incorporated physically into polyurethane coating as an additive. Experimental coatings were manufactured on a laboratory scale and applied by brush on steel and wood panels. The coated films were screened against Gram-negative bacteria, Gram-positive bacteria and fungi to evaluate the antimicrobial activity of the prepared thiazole derivatives. A flame retardant property of the prepared thiazole derivative compounds was evaluated by measuring the limiting oxygen index (LOI) of the coated films. The mechanical properties of these coated films were also examined to evaluate the drawbacks of the thiazole derivative additive. The obtained results showed that, the physical incorporation of thiazole derivative have led to improve the antimicrobial, flame retardancy and mechanical properties of polyurethane coating.