Background: Asthma is a chronic disorder of the bronchial tree, characterized by completely or partially reversible airway obstruction, which may improve spontaneously or may subside only after specific therapy. Airway hyper responsiveness is defined as the narrowing of the airways as response to a variety of stimuli. This study aimed to assess the role of serum periostin in diagnosis of asthmatic children and it's relation to etiology either atopic or infective. Method: A prospective Cross sectional study was carried out at pulmonary unit pediatric department, in Zagazig University hospitals during the period from December 2016 to January 2018. Forty six patients diagnosed as bronchial asthma were recruited in the study and full history and clinical examination was taken full lab was taken such as complete blood count, C reactive protein, erythrocyte sedimentation rate, IGE level and Serum periostin was taken. Pulmonary function tests (PFTs) was performed with spirometer. Statistical analysis was done for these data. Results: Serum periostin was significantly higher in asthmatics and in patients with uncontrolled compared to controlled asthma. It was significantly higher in those with severe and moderate asthma than those with mild asthma. Significant negative correlation between serum periostin level and pulmonary function parameters were detected..A logistic regression analysis showed that serum periostin level was predictor of impaired forced expiratory volume 1 (FEV1) in asthmatic children.
Conclusion: The study proved that serum levels of periostin, a new biomarker, were higher in asthmatic children. increase level of serum perostin in uncontrolled asthma and severe asthmatic attack.