Background: There are multiple treatment options for morphea, but all have limited success or a wide range of side effects. Platelet-rich plasma is an innovative type of contour defect therapy, with long-lasting morphea, good cosmetic outcomes and limited side effects. Aim: To assess clinically the effect of PRP in the treatment of patients with morphea. Methods: A pilot study conducted on five morphea patients were recruited for this study. Intradermal platelet rich plasma was injected into morphea plaques once weekly for 12 sessions. The disease severity and damage were evaluated at the first visit and after the last session using the Localized Scleroderma Assessment Tool. Results: After 12 sessions, one case showed significant improvement, three cases showed partial improvement and one showed no response. The modified Localized Skin Severity Index and Localized Scleroderma Damage Index were significantly reduced after treatment. Patients with short disease duration (< 1 year) showed better response. Conclusion: Platelet rich plasma is a successful option for patients with localized types of morphea with good cosmetic outcome and minimal side effects.
Key words: morphea, platelet-rich plasma, cosmetic outcome.