Background: Alopecia areata (AA) is an inflammatory, nonscarring form of hair loss. Important variations in the clinical presentation of alopecia areata have been detected, extending from small, well-circumscribed blotches of hair loss to a complete absence of scalp and body hair. AA is an immunologically mediated disease that causing damage of hair follicles and lead t hair loss. Etiology of Alopecia areata is not well known.
Objective: To measure serum levels of (P-selectin and E-selectin) in patients with AA in relation to the control group. We try to find out the relation between serum levels of P-selectin and E-selectin) and selected clinical considerations, including the severity and the activity of alopecia areata.
Methods: This case-control study was performed on 56 subjects of both sexes at Dermatology, Venereology and Andrology Department outpatient clinic & Department of Clinical Pathology at Zagazig University during the period from May 2018 to November 2018. The 56 subjects were divided into: Case group: 28 patients with different types of Alopecia areata were included in this study. Control group: 28 healthy subjects with age and sexes matched with AA patients.
Results: Statistically significantly high levels of P and E-selectins were found in AA patients as compared with the control group. Serum levels of soluble forms of E- and P-selectins correlated with the activity and severity of AA.
Conclusion: This study shows that P and E-selectin can play a significant role in the pathogenesis of AA and may possibly be a target of upcoming therapies in this disease.