Background : Nocturnal Enuresis (NE) and its comorbid psychiatric disorders affect Quality of Life (QoL) of children and their families. This sample survey cross sectional study was carried out in pediatric department in coordination with psychiatric department from June 2018 to June 2019 to detect frequency of psychiatric disorders and associated risk factors in children and adolescents with NE in Zagazig University Hospitals to improve health and QoL of them. Methods: Thirty patients (16 male, 14 female) with NE aged 5 to 18 years were subjected to history taking and examination. A questionnaire was distributed to children and parents. An interview was done with cases with NE according to Diagnostic and Statistical Manual of Mental disorders (DSM- V) for application of the arabic version of Children' s Manifest Anxiety Scale "CMAS" , Children Depression Inventory (CDI), arabic abuse and neglect scale for children , Child Behavior Checklist (CBCL-6-18), Pediatric Incontinence Questionnaire (PinQ) and DSM- V edition criteria for diagnosis of Attention Deficit Hyperactivity Disorder (ADHD) and Oppositional Defiant Disorder (ODD) .Results: 73.3% of patients had their QoL affected , 70% of had behavioral abnormalities, 40% had decreased self-esteem and 36.7 % had high degrees of child abuse, 33.3 % had psychosocial problems, 83.3 % had parent stress and anxiety, 63.3% had ADHD, 50 % had ODD, 66.7 % had depression ,and all of them had anxiety with different degrees .Conclusion: Children with NE presented with increased rates of psychiatric disorders, impaired self-esteem and reduced QoL affects their relationships with friends.