Abstract

Background: Infections with human papillomavirus (HPV) are the third basic skin ailment experienced. Verrucae are considerate epithelial expansions of skin and mucosa achieved by infection with HPV. No treatment works for all verrucae on all patients, however numerous choices are accessible and, with time and tolerance, most verrucae will react to treatment. In this study, we compared the efficacy of immunotherapy by Candida albicans antigen injection and cryosurgery on Verrucae lesions.

Methods: A clinical trial was done with forty patients with verruca vulgaris; they were randomly divided into two groups. First group received intralesional injection of 0.3ml of candida albicans antigen repeated every 2 weeks until complete improvement of all warts or for a maximum of five sessions. The second group was treated by cryosurgery with liquid nitrogen at two weeks interval for a maximum of five sessions or until clearance of all lesions.

Results: The patients showed a highly significant therapeutic response to cryosurgery compared to immunotherapy (P