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235794

Prognostic relevance of immunohistochemical expression of Sox2, YAP1, and IMP3 in non-muscle invasive bladder cancer

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Pathology

Abstract

BACKGROUND: Despite advances in intravesical therapy and surgery, up to 30% of NMIBC suffer progression to MIBC.
OBJECTIVES: To identify the valuable prognostic biomarkers, we analyzed the immunohistochemical expression of Sox2, YAP1, and IMP3 in 60 cases of NMIBC who underwent TURBT with adjuvant intravesical bacillus-Calmette-Guerin (BCG).
METHODS: The immunohistochemical expression was done on a sixty patients who complained from primary papillary superficial transitional cell carcinoma (TCC) of the urinary bladder (Stage Ta-T1).Their predicting role for recurrence, progression, progression-free survival (PFS), and recurrence-free survival (RFS) was assessed.
RESULTS: High Sox2 expression was observed in 55% of NMIBC cases, and it was significantly associated with the tumor size, grade, and stage (p < /p>

DOI

10.21608/zumj.2022.133357.2555

Keywords

SOX2, YAP1, IMP3, Non-muscle-invasive bladder cancer, Prognostic markers

Authors

First Name

Hanaa

Last Name

Ibrahim

MiddleName

Mohamed

Affiliation

Pathology faculty of medicine Zagazig university

Email

dr.hanaaghatwary@gmail.com

City

-

Orcid

-

First Name

Aziza E.

Last Name

Abdelrahman

MiddleName

-

Affiliation

Pathology department, faculty of medicine, zagazig university, Egypt

Email

azaelsayed@gmail.com

City

Zagazig

Orcid

0000-0003-4074-4779

First Name

Amira

Last Name

Elwan

MiddleName

-

Affiliation

clinical oncology, faculty of medicine

Email

amira_elwan@yahoo.com

City

-

Orcid

-

First Name

Eman

Last Name

Elsebai

MiddleName

Ali

Affiliation

Clinical oncology department

Email

dremanelsebai@yahoo.com

City

-

Orcid

0000-0001-5575-9071

First Name

Ahmed

Last Name

Eliwa

MiddleName

-

Affiliation

Urology department , Zagazig University

Email

ahmedeliwafarag@gmail.com

City

-

Orcid

0000-0002-2866-2423

First Name

Samah S.

Last Name

Elbasateeny

MiddleName

-

Affiliation

pathology department,faculty of medicine,zagazig university,Egypt

Email

samah_elbasateeny@yahoo.com

City

Zagazig

Orcid

-

Volume

28

Article Issue

6

Related Issue

37452

Issue Date

2022-11-01

Receive Date

2022-04-18

Publish Date

2022-11-01

Page Start

1,414

Page End

1,429

Print ISSN

1110-1431

Online ISSN

2357-0717

Article File

ZUMJ_Volume 28_Issue 6_Pages 1414-1429.pdf

PDF . 1.6MB

Link

https://zumj.journals.ekb.eg/article_235794.html

Detail API

https://zumj.journals.ekb.eg/service?article_code=235794

Order

28

Type

Original Article

Type Code

273

Publication Type

Journal

Publication Title

Zagazig University Medical Journal

Publication Link

https://zumj.journals.ekb.eg/

MainTitle

Prognostic relevance of immunohistochemical expression of Sox2, YAP1, and IMP3 in non-muscle invasive bladder cancer

Details

Type

Article

Created At

22 Jan 2023