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229679

Mechanism of actions of some common toxic agents causing toxic cardiomyopathy

Article

Last updated: 22 Jan 2023

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Subjects

-

Tags

Forensic Medicine & Toxicology

Abstract

Background: Toxic cardiomyopathy is related to heart failure in many cases and may lead to death. We focused on the mechanisms by which some common toxic agents cause cardiomyopathy. We searched in articles, case reports, experimental and clinical studies on this topic
Our results have shown that the heart or the cardiovascular system is one of the most affected systems by toxic agents. We summarized studies which mentioned some common cause such as; "Anti-cancer drugs", "Anti-diabetic drugs", "Cocaine", "Ethanol", "Heavy Metals", and "Digitalis drugs" and their mechanism of action inducing cardiotoxicity.. We concluded that mechanisms underlying toxic cardiomyopathy are complicated and variable. However, they generally include disruption of cell bioenergetics and intracellular calcium handling. It is also involved in: production of reactive oxygen species (ROS), development of oxidative stress and apoptosis induction.
Conclusion: Toxic agents have a very harmful effect on the heart producing cardiomyopathy and heart failure. A lot of drugs and environmental toxins can produce cardiotoxicity including; anti-cancer drugs, anti-diabetic drugs, cocaine, ethanol, CO, and heavy metals their mechanisms of action are complicated and included many factors.

DOI

10.21608/zumj.2022.125953.2492

Keywords

"Cardiomyopathy", "toxicity, "Heart Failure" "toxic agent, "Digitalis"

Authors

First Name

Abdelazem

Last Name

Khaled

MiddleName

-

Affiliation

Faculty of medicine, Zagazig University, Zagazig, Sharkia, Egypt

Email

abdelazemkhaled@ymail.com

City

Zagazig, Sharkia

Orcid

0000-0001-7582-3149

First Name

Meriet

Last Name

Mohamed

MiddleName

Ahmed

Affiliation

Faculty of medicine, Zagazig University, Zagazig, Sharkia, Egypt

Email

merietahmed82@gmail.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Gheith

MiddleName

Hamdy

Affiliation

Faculty of medicine, Zagazig University, Zagazig, Sharkia, Egypt

Email

ahmedhamdy20053@gmail.com

City

-

Orcid

-

First Name

Hala

Last Name

Mohamed

MiddleName

-

Affiliation

Faculty of medicine, Zagazig University, Zagazig, Sharkia, Egypt

Email

halamohamedx4@gmail.com

City

-

Orcid

-

First Name

Goda

Last Name

abdellatief

MiddleName

Ibrahim

Affiliation

faculty of medicine, zagazig university, zagazig, sharkia, egypt

Email

godaibrhim98@gmail.com

City

-

Orcid

-

First Name

Rana

Last Name

Fouad

MiddleName

-

Affiliation

faculty of medicine, zagazig university, zagazig, sharkia, egypt

Email

fouadrana69@gmail.com

City

-

Orcid

-

First Name

Abdulrahman

Last Name

Tantawy

MiddleName

Mohamed

Affiliation

faculty of medicine, zagazig university, zagazig, sharkia, egypt

Email

abdelrahmantantawy00@gmail.com

City

-

Orcid

-

First Name

Ereny

Last Name

Melad

MiddleName

-

Affiliation

Faculty of medicine, Zagazig University, Zagazig, Sharkia, Egypt

Email

erenymelad77@gmail.com

City

-

Orcid

-

First Name

Haitham

Last Name

Magdy

MiddleName

-

Affiliation

faculty of medicine, zagazig university, zagazig, sharkia, egypt

Email

haithammagdy5@hotmail.com

City

-

Orcid

-

First Name

Youssef

Last Name

Elkordi

MiddleName

Hesham

Affiliation

zagazig university faculty of medicine

Email

yf.ki2000@gmail.com

City

zagazig

Orcid

-

First Name

Ahmed

Last Name

Mohamed

MiddleName

Adel

Affiliation

Faculty of medicine, Zagazig University, Zagazig, Sharkia, Egypt

Email

ahmed20adel00@gmail.com

City

-

Orcid

-

Volume

28

Article Issue

6

Related Issue

37452

Issue Date

2022-11-01

Receive Date

2022-03-11

Publish Date

2022-11-01

Page Start

1,184

Page End

1,188

Print ISSN

1110-1431

Online ISSN

2357-0717

Article File

ZUMJ_Volume 28_Issue 6_Pages 1184-1188.pdf

PDF . 264.4kB

Link

https://zumj.journals.ekb.eg/article_229679.html

Detail API

https://zumj.journals.ekb.eg/service?article_code=229679

Order

2

Type

Review Articles

Type Code

349

Publication Type

Journal

Publication Title

Zagazig University Medical Journal

Publication Link

https://zumj.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023