Background: The process of laryngoscopy, endotracheal intubation and extubation is usually associated with exaggerated hemodynamic response including, hypertension, tachycardia, increased intracranial and intraocular pressure. The aim of this study was to evaluate and compare effectiveness of the modified tolerable endotracheal tube TET with the classical one in relation to hemodynamic response during extubation in patients under general anesthesia. Patients and Methods: Sixty patients with physical status American Society of Anesthesiologists ASA I, II aged 21–60 years, scheduled to undergo elective laparoscopic cholystectomy. The patients were randomly divided into 2 groups (30 each), group C: Classic Endotracheal Tube (classic group) and group T: Tolerable endotracheal tube (TET); that receiving intratracheal 7ml 0.5% Bupivacaine. Hemodynamic parameters; Blood pressure (systolic, diastolic mean blood pressure) were evaluated during the extubation. Results: Classic group showed significantly higher HR than tolerable group at 10 & 20 min P =0.031, P = 0.025 respectively, at extubation P=0.001 and 3min post extubation p = 0.003. Regarding MBP, group C showed significantly higher reading than group T at 20 min P=0.032 after induction and at extubation time P=0.002. Conclusion: Spraying intratracheal 7 ml of bupivacaine 0.5mg via TET can decrease the incidence of complications in the form of hemodynamic instability on emergence from general anesthesia GA.