ABSTRACT
Background: Neonatal sepsis remains one of the leading causes of morbidity and mortality among term and preterm infants. Although advances in neonatal care have improved survival and reduce complication in preterm infants, sepsis still contributes significantly to mortality and morbidity among very low birth weight infants in neonatal intensive care unit (NICU), Aim and Objectives: the of the study is an Early detection of neonatal sepsis and this can be reached by assessment of validity of IL6 and High Sensitive CRP and compare between validity of IL6 and High sensitive CRP in diagnosis of neonatal sepsis, Patients and Methods: this is a case control study was conducted in Neonatal Intensive Care Unit in Zagazig university hospital during a period of 8 months from December 2018 to August 2019, the study was conducted on twenty septic neonates compared with another twenty healthy neonate without any obstetric complications, high sensitive CRP and IL6 were evaluated in all participant, Results: the results revealed that Significant area under curve with cutoffs >19.2 and >75.3,Sensitivity of HS-CRP were 96% and 95% respectively and Sensitivity of IL6 were 88.8% and 90.2% respectively, Conclusion: the IL-6 is the highly sensitive marker and CRP is the more specific marker for the identification of neonatal sepsis