Many reaserches have shown associations between inflammatory markers and the risk of cognitive functions decline. Higher serum levels of CRP,IL-6 and TNF-α are associated with deteriorating cognitive function in elderly. The goal of this reaserch was to detect cognitive impairment in elderly individuals with diabetes and their relation to hs-CRP,IL-6 and TNF-α in those individuals. Two hundred fifty-five elderly individuals which were divided into 3 groups according to present or absence of diabetes together with level of diabetes control; Group I: 85 elderly individuals without diabetes, Group II: 85 elderly patients with controlled diabetes. Group III: 85 elderly patients with uncontrolled diabetes. Routine laboratory investigations together with lipid profile , hs- CRP,IL-6 and TNF-α were analyzed in three groups using blood serum sample then correlated to degree of cognitive impairment using mini mental state examination (MMSE). The present study proved that a statistical significant negative correlation between hs-CRP and MMS score examination in total population was found , there is statistical significant negative correlation between hs-CRP ,IL-6 ,TNF-α and MMS score examination in total elderly subjects with diabetes.. As well, there is significant positive correlation between hs-CRP and parameters of diabetic control So, estimation of inflammatory markers in elderly patients with diabetes may be a reliable indicator to identify and anticipate cognitive dysfunction in such individuals.
KEYWORDS: hs-CRP,IL-6, TNF-α , cognitive function, elderly diabetics